6-METHOXY-2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID

6-METHOXY-2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID - Names and Identifiers

Name	6-Methoxy-1H-indole-3-carboxylic acid
Synonyms	6-Methoxy-3-indolecarboxylic Acid 6-METHOXYINDOLE-3-CARBOXYLIC ACID Indole-3-carboxylic acid, 6-methoxy- 6-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID 6-Methoxy-1H-indole-3-carboxylic acid 1H-Indole-3-carboxylicacid, 6-Methoxy- 1H-Indole-3-carboxylic acid, 6-methoxy- 6-METHOXY-2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID
CAS	90924-43-9
InChI	InChI=1/C10H9NO3/c1-14-6-2-3-7-8(10(12)13)5-11-9(7)4-6/h2-5,11H,1H3,(H,12,13)

6-METHOXY-2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID - Physico-chemical Properties

Molecular Formula	C10H9NO3
Molar Mass	191.18
Density	1.381g/cm³
Boling Point	447.575°C at 760 mmHg
Flash Point	224.486°C
Vapor Presure	0mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.677

6-METHOXY-2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID - Reference Information

Use

substituted indole-3-carboxylic acid compounds are a class of compounds having an indole ring structure and a carboxyl group at the 3-position, substituted indole -3-carboxylic acid can be used for the synthesis of Spiro compounds with special physiological activity, for the treatment of mental illness, stomach disease, migraine and so on. The use of these compounds is very extensive, is an important pesticide, pharmaceutical intermediates.

preparation

There are two methods for the synthesis of 6-methoxy-indole-3-carboxylic acid compounds, the first one: 6-methoxy-indole-3-carbaldehyde was prepared from 6-methoxy-indole by Vilsmeier-Hacck reaction, then, the aldehyde group was oxidized by potassium permanganate to obtain 6-methoxy-indole-3-carboxylic acid. Second: hydrolysis of 6-methoxy-indole-3-carbonitrile, the method mainly has three steps, firstly, 6-methoxy-indole was used as raw material to prepare 6-methoxy-indole-3-carbaldehyde by Vilsmeier-Hacck reaction, then, 6-methoxy-indole-3-carbonitrile was synthesized by one-step reaction of 6-methoxy-indole-3-carbaldehyde and hydroxylamine hydrochloride, re-hydrolysis gave 6-methoxy-indole-3-carboxylic acid. The reaction formula for the synthesis of 6-methoxy-3-indolecarboxylic acid is shown below:

Last Update：2024-04-09 21:32:09